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Aki non da Vinci
Aki non da Vinci
@qwertziop@chaos.social  ·  activity timestamp 4 days ago
Aki non da Vinci
Aki non da Vinci
@qwertziop@chaos.social  ·  activity timestamp 4 days ago
Esther Payne :bisexual_flag: and 1 other boosted
Tom Kindlon
Tom Kindlon
@tomkindlon@disabled.social  ·  activity timestamp 2 weeks ago
Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study — Thapaliya et al. "Our study identified altered signal intensity, abnormal tissue microstructure, and imbalanced neurochemicals in long COVID and COVID-19 recovered healthy controls. Importantly, we also found a significant association between T1w/T2w signal intensity and clinical measures, suggesting a potential link between myelin content and symptom severity."
Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study — Thapaliya et al. "Our study identified altered signal intensity, abnormal tissue microstructure, and imbalanced neurochemicals in long COVID and COVID-19 recovered healthy controls. Importantly, we also found a significant association between T1w/T2w signal intensity and clinical measures, suggesting a potential link between myelin content and symptom severity."
Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study — Thapaliya et al. "Our study identified altered signal intensity, abnormal tissue microstructure, and imbalanced neurochemicals in long COVID and COVID-19 recovered healthy controls. Importantly, we also found a significant association between T1w/T2w signal intensity and clinical measures, suggesting a potential link between myelin content and symptom severity."
ajuvo ✔ and 3 others boosted
JB 🐎 :neuro:
JB 🐎 :neuro:
@AnAutieAtUni@beige.party  ·  activity timestamp 3 weeks ago
nyx mir
nyx mir
@NyxMir@sunny.garden  ·  activity timestamp 2 weeks ago
Pubmed screenshot: Objectives: Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case [highlighted] of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to identify the causative ingredients [end highlight] of the 24-flavour herbal tea in the inhibition of CYP3A4 metabolism. Methods: Two commercially available 24- flavour tea products purchased in Hong Kong and the six plant constituents were tested for their CYP3A4 inhibitory effects utilizing an in- vitro fluorometric assay. Key findings: Of the commercially available teas available in Hong Kong, the most potent inhibitory effect was observed with the tea consumed in the initial clinical case. Of the six universal constituents, [highlight] chrysanthemum 5 the greatest inhibitory effect, iW LEW C50 of 95.7 ug/ml. Dandelion, liquorice and bishop's weed have IC50 of 140.6, 148.4 and 185.5 pg/ml, respectively. Field mint and Japanese honeysuckle have wearker inhibitory effect on CYP3A4 with IC50 of 1153.3 and 1466.6 ug/ml.
Pubmed screenshot: Objectives: Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case [highlighted] of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to identify the causative ingredients [end highlight] of the 24-flavour herbal tea in the inhibition of CYP3A4 metabolism. Methods: Two commercially available 24- flavour tea products purchased in Hong Kong and the six plant constituents were tested for their CYP3A4 inhibitory effects utilizing an in- vitro fluorometric assay. Key findings: Of the commercially available teas available in Hong Kong, the most potent inhibitory effect was observed with the tea consumed in the initial clinical case. Of the six universal constituents, [highlight] chrysanthemum 5 the greatest inhibitory effect, iW LEW C50 of 95.7 ug/ml. Dandelion, liquorice and bishop's weed have IC50 of 140.6, 148.4 and 185.5 pg/ml, respectively. Field mint and Japanese honeysuckle have wearker inhibitory effect on CYP3A4 with IC50 of 1153.3 and 1466.6 ug/ml.
Pubmed screenshot: Objectives: Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case [highlighted] of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to identify the causative ingredients [end highlight] of the 24-flavour herbal tea in the inhibition of CYP3A4 metabolism. Methods: Two commercially available 24- flavour tea products purchased in Hong Kong and the six plant constituents were tested for their CYP3A4 inhibitory effects utilizing an in- vitro fluorometric assay. Key findings: Of the commercially available teas available in Hong Kong, the most potent inhibitory effect was observed with the tea consumed in the initial clinical case. Of the six universal constituents, [highlight] chrysanthemum 5 the greatest inhibitory effect, iW LEW C50 of 95.7 ug/ml. Dandelion, liquorice and bishop's weed have IC50 of 140.6, 148.4 and 185.5 pg/ml, respectively. Field mint and Japanese honeysuckle have wearker inhibitory effect on CYP3A4 with IC50 of 1153.3 and 1466.6 ug/ml.
Health Self Defense ❤️‍🔥😷
Health Self Defense ❤️‍🔥😷
@healthselfdefense@kolektiva.social  ·  activity timestamp 2 weeks ago
nyx mir
nyx mir
@NyxMir@sunny.garden  ·  activity timestamp 2 weeks ago
Pubmed screenshot: Objectives: Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case [highlighted] of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to identify the causative ingredients [end highlight] of the 24-flavour herbal tea in the inhibition of CYP3A4 metabolism. Methods: Two commercially available 24- flavour tea products purchased in Hong Kong and the six plant constituents were tested for their CYP3A4 inhibitory effects utilizing an in- vitro fluorometric assay. Key findings: Of the commercially available teas available in Hong Kong, the most potent inhibitory effect was observed with the tea consumed in the initial clinical case. Of the six universal constituents, [highlight] chrysanthemum 5 the greatest inhibitory effect, iW LEW C50 of 95.7 ug/ml. Dandelion, liquorice and bishop's weed have IC50 of 140.6, 148.4 and 185.5 pg/ml, respectively. Field mint and Japanese honeysuckle have wearker inhibitory effect on CYP3A4 with IC50 of 1153.3 and 1466.6 ug/ml.
Pubmed screenshot: Objectives: Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case [highlighted] of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to identify the causative ingredients [end highlight] of the 24-flavour herbal tea in the inhibition of CYP3A4 metabolism. Methods: Two commercially available 24- flavour tea products purchased in Hong Kong and the six plant constituents were tested for their CYP3A4 inhibitory effects utilizing an in- vitro fluorometric assay. Key findings: Of the commercially available teas available in Hong Kong, the most potent inhibitory effect was observed with the tea consumed in the initial clinical case. Of the six universal constituents, [highlight] chrysanthemum 5 the greatest inhibitory effect, iW LEW C50 of 95.7 ug/ml. Dandelion, liquorice and bishop's weed have IC50 of 140.6, 148.4 and 185.5 pg/ml, respectively. Field mint and Japanese honeysuckle have wearker inhibitory effect on CYP3A4 with IC50 of 1153.3 and 1466.6 ug/ml.
Pubmed screenshot: Objectives: Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case [highlighted] of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to identify the causative ingredients [end highlight] of the 24-flavour herbal tea in the inhibition of CYP3A4 metabolism. Methods: Two commercially available 24- flavour tea products purchased in Hong Kong and the six plant constituents were tested for their CYP3A4 inhibitory effects utilizing an in- vitro fluorometric assay. Key findings: Of the commercially available teas available in Hong Kong, the most potent inhibitory effect was observed with the tea consumed in the initial clinical case. Of the six universal constituents, [highlight] chrysanthemum 5 the greatest inhibitory effect, iW LEW C50 of 95.7 ug/ml. Dandelion, liquorice and bishop's weed have IC50 of 140.6, 148.4 and 185.5 pg/ml, respectively. Field mint and Japanese honeysuckle have wearker inhibitory effect on CYP3A4 with IC50 of 1153.3 and 1466.6 ug/ml.
Health Self Defense ❤️‍🔥😷
Health Self Defense ❤️‍🔥😷
@healthselfdefense@kolektiva.social  ·  activity timestamp 2 weeks ago
Tom Kindlon
Tom Kindlon
@tomkindlon@disabled.social  ·  activity timestamp 2 weeks ago
Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study — Thapaliya et al. "Our study identified altered signal intensity, abnormal tissue microstructure, and imbalanced neurochemicals in long COVID and COVID-19 recovered healthy controls. Importantly, we also found a significant association between T1w/T2w signal intensity and clinical measures, suggesting a potential link between myelin content and symptom severity."
Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study — Thapaliya et al. "Our study identified altered signal intensity, abnormal tissue microstructure, and imbalanced neurochemicals in long COVID and COVID-19 recovered healthy controls. Importantly, we also found a significant association between T1w/T2w signal intensity and clinical measures, suggesting a potential link between myelin content and symptom severity."
Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study — Thapaliya et al. "Our study identified altered signal intensity, abnormal tissue microstructure, and imbalanced neurochemicals in long COVID and COVID-19 recovered healthy controls. Importantly, we also found a significant association between T1w/T2w signal intensity and clinical measures, suggesting a potential link between myelin content and symptom severity."
Chris Espinosa and 1 other boosted
JuneSim63 💚
JuneSim63 💚
@junesim63@mstdn.social  ·  activity timestamp 3 weeks ago
Tom Kindlon
Tom Kindlon
@tomkindlon@disabled.social  ·  activity timestamp 3 weeks ago
PRESS RELEASE Groundbreaking myalgic encephalomyelitis study identifies over 250 core genes, shared biology with long COVID, and dozens of drug repurposing opportunities The study reinforces that ME is a complex multisystemic condition with a clear genetic basis and lays the foundation for future clinical trials that could be faster to recruit and more likely to succeed Read our FAQs OXFORD, UK – 4 December 2025 – PrecisionLife today announced new findings from the most detailed genetic analysis of myalgic encephalomyelitis (ME, also known as ME/CFS) ever conducted, revealing more than 250 core genes associated with the disease, including 76 genes linked with long COVID, and uncovering dozens of drug repurposing opportunities supported by genetic biomarker tests, offering potential for faster and lower-risk routes to developing targeted treatments. The study, now available as a pre-print and submitted for peer review, applied PrecisionLife's AI-led combinatorial analytics platform to analyze genomic data from two DecodeME cohorts together with UK Biobank to confirm reproducibility of results across three independent datasets. The analysis identified 7,555 genetic variants (including the 8 identified by the recent DecodeME GWAS study ), that were consistently associated with increased disease risk in three different populations.
PRESS RELEASE Groundbreaking myalgic encephalomyelitis study identifies over 250 core genes, shared biology with long COVID, and dozens of drug repurposing opportunities The study reinforces that ME is a complex multisystemic condition with a clear genetic basis and lays the foundation for future clinical trials that could be faster to recruit and more likely to succeed Read our FAQs OXFORD, UK – 4 December 2025 – PrecisionLife today announced new findings from the most detailed genetic analysis of myalgic encephalomyelitis (ME, also known as ME/CFS) ever conducted, revealing more than 250 core genes associated with the disease, including 76 genes linked with long COVID, and uncovering dozens of drug repurposing opportunities supported by genetic biomarker tests, offering potential for faster and lower-risk routes to developing targeted treatments. The study, now available as a pre-print and submitted for peer review, applied PrecisionLife's AI-led combinatorial analytics platform to analyze genomic data from two DecodeME cohorts together with UK Biobank to confirm reproducibility of results across three independent datasets. The analysis identified 7,555 genetic variants (including the 8 identified by the recent DecodeME GWAS study ), that were consistently associated with increased disease risk in three different populations.
PRESS RELEASE Groundbreaking myalgic encephalomyelitis study identifies over 250 core genes, shared biology with long COVID, and dozens of drug repurposing opportunities The study reinforces that ME is a complex multisystemic condition with a clear genetic basis and lays the foundation for future clinical trials that could be faster to recruit and more likely to succeed Read our FAQs OXFORD, UK – 4 December 2025 – PrecisionLife today announced new findings from the most detailed genetic analysis of myalgic encephalomyelitis (ME, also known as ME/CFS) ever conducted, revealing more than 250 core genes associated with the disease, including 76 genes linked with long COVID, and uncovering dozens of drug repurposing opportunities supported by genetic biomarker tests, offering potential for faster and lower-risk routes to developing targeted treatments. The study, now available as a pre-print and submitted for peer review, applied PrecisionLife's AI-led combinatorial analytics platform to analyze genomic data from two DecodeME cohorts together with UK Biobank to confirm reproducibility of results across three independent datasets. The analysis identified 7,555 genetic variants (including the 8 identified by the recent DecodeME GWAS study ), that were consistently associated with increased disease risk in three different populations.
Dr Joe Pajak
Dr Joe Pajak
@JoePajak@mstdn.science  ·  activity timestamp 3 weeks ago