#Statistics rant follows - feel free to tune out.
The Vaccine Efficacy scale is one of the silliest scales in the whole #epidemiology. Formally it is just 1 - RR (relative risk), and while the RR is a personal fav of mine when comparing event rates, the 1 - RR is an idiotic Frankestein for the following reasons ....
1. If one uses a model (such as a Poisson or Neg Binom #GLM) to compute it, then one is fitting a non-canonical scale to often small datasets; under these circumstances all the standard central limit theorems lose their typically fast convergence rates and you run the risk of your inference being a hot pile of numerical garbage unless ofc you have an unrealistically huge sample.
