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Scientific Frontline
Scientific Frontline
@sflorg@mastodon.social  ·  activity timestamp 4 weeks ago

New research reveals how a class of #neurons that help coordinate communication in the #brain link up with their target cells, identifying two #molecules that must be present before synapses, the structures that carry signals between these partners, can form on the target neurons.
#Neuroscience #MolecularBiology #sflorg
https://www.sflorg.com/2026/01/ns01132601.html

One way brain ‘conductors’ find precise connection to target cells

Study in mice confirms molecules that link inhibitory, excitatory neurons
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Fabrizio Musacchio
Fabrizio Musacchio
@FabMusacchio@mastodon.social  ·  activity timestamp 4 weeks ago

🧠 New paper by Ishida et al who show how #neurons in the #Drosophila central complex implement vector inversion via #calcium spikes.

A single #NeuronalPopulation can flip the sign of its encoded vector by switching biophysical #spiking modes, enabling coordinate transformations through #PopulationDynamics rather than circuit switching.

Cool as it shows that computation is not imposed by the circuit, but emerges from the neuron’s own dynamics.

🌍https://doi.org/10.1016/j.cell.2025.11.040

#Neuroscience #CompNeuro

Diagram showing how single neuron activity influences population activity, with vectors, signals, and neural pathways. Graphical abstract of the paper.
Diagram showing how single neuron activity influences population activity, with vectors, signals, and neural pathways. Graphical abstract of the paper.
Diagram showing how single neuron activity influences population activity, with vectors, signals, and neural pathways. Graphical abstract of the paper.

Neuronal calcium spikes enable vector inversion in the Drosophila brain

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