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kcarruthers

Researchers are starting to argue that #Endometriosis is like a #Cancer - Reproductive Sciences

https://link.springer.com/article/10.1007/s43032-025-02024-0

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Text Shot: Endometriosis (EMS) is a non-cancerous invasive condition where tissue resembling the lining of the uterus is found outside of the uterine cavity. Endometriotic lesions have been found in nearly every organ of the body. This review highlights examples of EMS exhibiting all eight established hallmarks of cancer: hyperproliferation (e.g. through estrogen signalling), evasion of growth suppression (e.g. through progesterone resistance), immunosurveillance evasion (e.g. through reduction of natural killer cell cytotoxicity), enabling replicative immortality (e.g. through increased telomere length), invasion (e.g. through epithelial-to-mesenchymal transition), induction of angiogenesis (e.g. through upregulation of hypoxia-inducible factors), resistance to apoptosis (e.g. through increased expression of survivin), and deregulation of cellular metabolism (e.g. through increased production of lactate). Therefore, despite being considered a non-cancerous, benign condition, EMS is…

SpringerLink

Endometriosis and the Hallmarks of Cancer - Reproductive Sciences

Endometriosis (EMS) is a non-cancerous invasive condition where tissue resembling the lining of the uterus is found outside of the uterine cavity. Endometriotic lesions have been found in nearly every organ of the body. This review highlights examples of EMS exhibiting all eight established hallmarks of cancer: hyperproliferation (e.g. through estrogen signalling), evasion of growth suppression (e.g. through progesterone resistance), immunosurveillance evasion (e.g. through reduction of natural killer cell cytotoxicity), enabling replicative immortality (e.g. through increased telomere length), invasion (e.g. through epithelial-to-mesenchymal transition), induction of angiogenesis (e.g. through upregulation of hypoxia-inducible factors), resistance to apoptosis (e.g. through increased expression of survivin), and deregulation of cellular metabolism (e.g. through increased production of lactate). Therefore, despite being considered a non-cancerous, benign condition, EMS is highly cancer-like in its behaviours to promote invasion and ectopic survival. The presence of all hallmarks of cancer amongst endometriotic behaviours highlights that to expand understanding of endometriotic metastasis, as well as potential modes for management of EMS, it may be possible to leverage the larger knowledge base associated with cancer.

Angela Antunovic boosted

Lin Nah

@lin@mastodon.nz · 2 months ago

Please sign this petition by Endo Warriors Aotearoa https://www.endowarriorsaotearoa.com/
It will be submitted this week

To: Minister of Health Simeon Brown, and Te Whatu Ora
Women, girls & people assigned female at birth with Endo deserve better: Demand guideline review now https://our.actionstation.org.nz/petitions/people-with-endometriosis-deserve-better-demand-review-of-the-national-guidelines

#Endometriosis affects more than 1 in 7 women, girls & those assigned female at birth in Aotearoa, yet national care guidelines haven't been updated since 2020

https://www.health.govt.nz/publications/diagnosis-and-management-of-endometriosis-in-new-zealand

More info about the campaign at https://www.endowarriorsaotearoa.com/

More info about Endo in NZ
https://nzendo.org.nz/

https://info.health.nz/conditions-treatments/womens-health/endometriosis

https://healthify.nz/health-a-z/e/endometriosis

Unfortunately there are many still untreated as I doubt the situation has improved since this 18 July 2024 article:

Hundreds of women left untreated as over 80% of referrals get declined https://nzendo.org.nz/endo-news/hundreds-of-women-left-untreated-as-over-80-of-referrals-get-declined/ or original at The Press https://www.thepress.co.nz/nz-news/350340056/hundreds-women-left-untreated-over-80-referrals-get-declined

#AoNZPol #NZPol