🧠 New preprint by Kim et al. (2025) from David Anderson’s lab: A line #attractor maintains aggressiveness during feeding in “hangry” mice 🍔🐁. Using in vivo #CalciumImaging and #rSLDS modeling, they show how moderate fasting stabilizes an aggression-related attractor in #VMHvl, while prolonged fasting collapses it, linking hunger, motivation, and aggression through #PopulationDynamics:
🌍 https://doi.org/10.1101/2025.10.16.682711
#Neuroscience #CompNeuro #Behavior #AttractorDynamics #Hypothalamus #2p #imaging
Fig. 3 | Prolonged fasting duration reveals biphasic effects on aggression and stability of VMHvlEsr1 attractor dynamics.
Fig. 2 | Moderate fasting enhances ramping and persistence in a VMHvlEsr1 latent slow mode.
Fig. 1 | Moderate food deprivation enhances aggression in male mice.