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Christos Argyropoulos MD PhD
@ChristosArgyrop@mastodon.social  ·  activity timestamp last week

Some of the conversations about #longcovid (LC) are delusional, frankly wrong and will actively harm people.

Learn to think through the groups of possibilities first after loosely defining #longcovid as the sequeala of the acute infection (perceived as a respiratory infection with some extra stuff by most). For example, in the absence of concrete evidence to the contrary (no such evidence exists), LC includes phenotypes of:

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Christos Argyropoulos MD PhD
@ChristosArgyrop@mastodon.social replied  ·  activity timestamp last week

1) irreversible damage (think myocardial infarction/stroke both in the covid and in the non covid settings),
2) potentially reversible (think autoimmunity/inflammation/vascular involvement after the virus has left the body) and
3) reversible damage (vital persistence leading to inflammation as a localized continuation of the acute infection, think of a urinary tract infection).

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Christos Argyropoulos MD PhD
@ChristosArgyrop@mastodon.social replied  ·  activity timestamp last week

Therapies against
🛑irreversible damage can never exist unless longevity/regenerative medicine research delivers in some unidentified time point after 2050,

💔potentially reversible autoimmune damage may exist but will probably require lifelong therapy unless CRISPR/CAR-T/CAR-NK deliver
🥳potentially reversible may exist, but will require prolonged and complex regimens that potentially vary according to local sites affected.

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Christos Argyropoulos MD PhD
@ChristosArgyrop@mastodon.social replied  ·  activity timestamp last week

Since no therapies have clearly been identified for any of the three and research has not even started for the feasible (2 and 3) categories, one is left with *prevention of infection* as the only mechanism to reduce the prevalence of #longcovid after repeated infections at the societal level and

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