So I'm reading https://www.medrxiv.org/content/10.1101/2025.08.08.25333305v1.full-text with interest as it ostensibly found metformin didn't meaningfully decrease Long COVID rates

and

participants didn't receive the metformin until a median five days after symptom onset

they cite other work that found a ~40% reduction in LC with metformin dose:

In the COVID-OUT randomized trial, the HR for participant-reported clinician diagnosis of LC in those randomized to 14 days of metformin was 0.59 (95% CI 0.39 to 0.89)

and I am left wondering if maybe "metformin should be taken as early as possible during acute COVID-19" is what the new study really suggests

#SARSCoV2#COVID#COVID19 #LongCOVID #metformin #CovidIsNotOver