Long COVID treatment study recruiting volunteers now in the USA:
trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid
This is the excellent Putrino lab! Participation criteria and contact info: https://clinicaltrials.gov/study/NCT06511063
Long COVID treatment study recruiting volunteers now in the USA:
trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid
This is the excellent Putrino lab! Participation criteria and contact info: https://clinicaltrials.gov/study/NCT06511063
In case you missed the article in freaking Nature that found ⚠️ MOST kids develop fatigue after acute SARS-CoV-2 https://www.nature.com/articles/s41598-025-24868-x two weeks ago,
a longitudinal analysis of the Children and Young People with Long COVID
the rate of some lasting fatigue in kids is ALMOST TWO THIRDS
Among 943 SARS-CoV-2-positive participants, 581 (61.6%) met CFQ [Chalder Fatigue Scale] case-ness at least once during follow-up
with consistent, chronic, unresolving fatigue in more than 1 in 6 kids after infection!
15.9% meet case-ness at all follow-ups.
the rate got worse over time!
The proportion of CFQ cases increased from 35.0% at 3-months to 40.2% at 24-months post-infection;
1/ 🧵
#SARSCoV2 #COVID #COVID19 #pandemic #LongCOVID #publicHealth #health
In case you missed the article in freaking Nature that found ⚠️ MOST kids develop fatigue after acute SARS-CoV-2 https://www.nature.com/articles/s41598-025-24868-x two weeks ago,
a longitudinal analysis of the Children and Young People with Long COVID
the rate of some lasting fatigue in kids is ALMOST TWO THIRDS
Among 943 SARS-CoV-2-positive participants, 581 (61.6%) met CFQ [Chalder Fatigue Scale] case-ness at least once during follow-up
with consistent, chronic, unresolving fatigue in more than 1 in 6 kids after infection!
15.9% meet case-ness at all follow-ups.
the rate got worse over time!
The proportion of CFQ cases increased from 35.0% at 3-months to 40.2% at 24-months post-infection;
1/ 🧵
#SARSCoV2 #COVID #COVID19 #pandemic #LongCOVID #publicHealth #health
With a symptom cluster around fatigue:
Among ever-cases (n=581), CFQ items relating to lacking in energy, feeling sleepy/drowsy, needing to rest more, and having problems with tiredness had the highest prevalences across follow-ups
And the recovery trajectories? They look pretty flat: https://www.nature.com/articles/s41598-025-24868-x/figures/3 (alt text: Mean trajectories of CFQ total score, by sex, age at time of infection, EHCP and/or learning difficulties at school. Each graph is really quite flat.)
2/2
#SARSCoV2 #COVID #COVID19 #pandemic #LongCOVID #publicHealth #health
In case you missed the article in freaking Nature that found ⚠️ MOST kids develop fatigue after acute SARS-CoV-2 https://www.nature.com/articles/s41598-025-24868-x two weeks ago,
a longitudinal analysis of the Children and Young People with Long COVID
the rate of some lasting fatigue in kids is ALMOST TWO THIRDS
Among 943 SARS-CoV-2-positive participants, 581 (61.6%) met CFQ [Chalder Fatigue Scale] case-ness at least once during follow-up
with consistent, chronic, unresolving fatigue in more than 1 in 6 kids after infection!
15.9% meet case-ness at all follow-ups.
the rate got worse over time!
The proportion of CFQ cases increased from 35.0% at 3-months to 40.2% at 24-months post-infection;
1/ 🧵
#SARSCoV2 #COVID #COVID19 #pandemic #LongCOVID #publicHealth #health
How Covid damages the brain and central nervous system, and how it is affecting our society and our children.
"Hardly anyone in the scientific, health or public policy arenas ever breathes a whisper of acknowledgement that current troubling escalations in violence, traffic accidents and severity, workforce faltering and long term disability trace back to the start of this pandemic. Hardly any of them even admit the pandemic is still ongoing.
One of the parents I mentioned was startled by my remark that I expected this. When I explained what I have laid out here, they said the violent child has always been unusual, but violence and wild irrationality came after the household caught COVID."
How Covid damages the brain and central nervous system, and how it is affecting our society and our children.
"Hardly anyone in the scientific, health or public policy arenas ever breathes a whisper of acknowledgement that current troubling escalations in violence, traffic accidents and severity, workforce faltering and long term disability trace back to the start of this pandemic. Hardly any of them even admit the pandemic is still ongoing.
One of the parents I mentioned was startled by my remark that I expected this. When I explained what I have laid out here, they said the violent child has always been unusual, but violence and wild irrationality came after the household caught COVID."
"Day 1096—Today marks 3 years exactly since a mild COVID infection put an end to my career, to my social life, to my ability to run, play, work, hope. 26,304 hours—and counting—lost to a virus that society insists is harmless. Here's a selection of artwork I made chronicling my journey."
I keep seeing more and more posts about how Covid magically now has fewer deaths than the flu. Please keep in mind a couple of things about data science and Covid.
As Covid deaths reporting continued into 2021 and 2022, more and more data reporters wanted to go "back to normal" and support that narrative, so the definition of a "Covid death" was changed. Depending on the state or other reporting agency, a "Covid death" can be assigned in different ways. For example, in 2021 New Hampshire changed Covid death assignment to only hospitalized patients taking specific meds. If you died from Covid but didn't fit this narrow definition, your death was recorded as something else, and not reported as a Covid death. Using limitations on the definition of cause of death, Covid deaths have been minimized for years by reporting agencies.
Many states and other groups see this type of data reportng and trending as meaningful for only the past 3 years. If the data reporting on excess mortality is presented with limited years, we no longer see the rise from pre-Covid excess mortality into the start of Covid; those years are no longer presented in the graphs and charts. It can appear that excess mortality is steady or even actually dropping, if the data reported are both tainted and limited.
Covid also contributes to deaths in a way that can be hidden for those who deny the affects that Covid has on the immune system and the damage it does to the body internally. This type of damage can be somewhat invisible, since it happens after the acute infection symptoms have cleared up or lessened. With so many people avoiding saying the word "Covid", and especially so many in the healthcare industry, those who are recording deaths on certificates are more likely to put the immediate cause - heart attack, stroke, kidney disease, etc. - instead of the actual driver of those diseases, which is Covid.
I have been present when a hospice worker recorded the death of a family member, and they actually asked me and my husband what they should put as the cause of death on the death certificate! We always want to think it's an official declaration, but given my experience, it could also be a family member stating the recorded cause of death for many people, thus hiding even more Covid deaths if the family do not want to say the word "Covid".
Many people continue to prefer to deny the lethality of Covid. They continue to say "it's mild" and "it's just like the flu/cold/allergies". And now we see this continued into the concept that somehow the flu causes more deaths than Covid. This is going to be repeated over and over, and more and more people will believe it, and then repeat it themselves. They will point to the flawed data and shoddy graphs to "prove" it.
Please keep this in mind as we go through another Covid wave, and enter another Winter season full of unmasked sick people trying to convince you it's best to go into work and school while spreading their illness to everyone. Covid did not stop being dangerous. The data is what became more dangerous.
#Covid #CovidIsNotOver#DataScience #LongCOVID#ExcessMortality#CovidDeaths
I keep seeing more and more posts about how Covid magically now has fewer deaths than the flu. Please keep in mind a couple of things about data science and Covid.
As Covid deaths reporting continued into 2021 and 2022, more and more data reporters wanted to go "back to normal" and support that narrative, so the definition of a "Covid death" was changed. Depending on the state or other reporting agency, a "Covid death" can be assigned in different ways. For example, in 2021 New Hampshire changed Covid death assignment to only hospitalized patients taking specific meds. If you died from Covid but didn't fit this narrow definition, your death was recorded as something else, and not reported as a Covid death. Using limitations on the definition of cause of death, Covid deaths have been minimized for years by reporting agencies.
Many states and other groups see this type of data reportng and trending as meaningful for only the past 3 years. If the data reporting on excess mortality is presented with limited years, we no longer see the rise from pre-Covid excess mortality into the start of Covid; those years are no longer presented in the graphs and charts. It can appear that excess mortality is steady or even actually dropping, if the data reported are both tainted and limited.
Covid also contributes to deaths in a way that can be hidden for those who deny the affects that Covid has on the immune system and the damage it does to the body internally. This type of damage can be somewhat invisible, since it happens after the acute infection symptoms have cleared up or lessened. With so many people avoiding saying the word "Covid", and especially so many in the healthcare industry, those who are recording deaths on certificates are more likely to put the immediate cause - heart attack, stroke, kidney disease, etc. - instead of the actual driver of those diseases, which is Covid.
I have been present when a hospice worker recorded the death of a family member, and they actually asked me and my husband what they should put as the cause of death on the death certificate! We always want to think it's an official declaration, but given my experience, it could also be a family member stating the recorded cause of death for many people, thus hiding even more Covid deaths if the family do not want to say the word "Covid".
Many people continue to prefer to deny the lethality of Covid. They continue to say "it's mild" and "it's just like the flu/cold/allergies". And now we see this continued into the concept that somehow the flu causes more deaths than Covid. This is going to be repeated over and over, and more and more people will believe it, and then repeat it themselves. They will point to the flawed data and shoddy graphs to "prove" it.
Please keep this in mind as we go through another Covid wave, and enter another Winter season full of unmasked sick people trying to convince you it's best to go into work and school while spreading their illness to everyone. Covid did not stop being dangerous. The data is what became more dangerous.
#Covid #CovidIsNotOver#DataScience #LongCOVID#ExcessMortality#CovidDeaths
So I'm reading https://www.medrxiv.org/content/10.1101/2025.08.08.25333305v1.full-text with interest as it ostensibly found metformin didn't meaningfully decrease Long COVID rates
and
participants didn't receive the metformin until a median five days after symptom onset
they cite other work that found a ~40% reduction in LC with metformin dose:
In the COVID-OUT randomized trial, the HR for participant-reported clinician diagnosis of LC in those randomized to 14 days of metformin was 0.59 (95% CI 0.39 to 0.89)
and I am left wondering if maybe "metformin should be taken as early as possible during acute COVID-19" is what the new study really suggests
#SARSCoV2#COVID#COVID19 #LongCOVID #metformin #CovidIsNotOver
Someone (you know who you are) pointed this https://www.sciencedirect.com/science/article/pii/S2589004224018959 out
which hints that maybe metformin's mechanism of action against LC might be to make it harder for C19 to establish viral reservoirs
haven't read the paper in depth but a very interesting notion
if true then we could expect to see meformin
