An Empirical Assessment of the Cost of Dichotomization of the Outcome of Clinical Trials https://onlinelibrary.wiley.com/doi/10.1002/sim.70402
"Burdening more participants than necessary is wasteful, costly, and unethical.

… trials with a binary outcome have larger sample sizes on average, but also larger standard errors and fewer statistically significant results. We conclude that researchers tend to increase the sample size to compensate for the low information content of #binary outcomes, but not sufficiently.
… estimate that on average, only about 60% of the information is retained after #dichotomization
… hope that quantifying the loss of information will discourage researchers from dichotomizing continuous outcomes"
#statistics #rstats