Science is the best way to produce facts about reality. The best, at least, that limited human beings have devised so far. Yet, not even scientists quite seem to understand how scientific knowledge is generated. This is not only a philosophical but also a practical problem, as our misunderstandings affect the quality of our research and limit the directions it can take. In light of this, it may be good if we reflected a bit more on how we do science — to become better researchers through philosophy. Here, I provide an accessible introduction to a philosophical approach that achieves precisely this: William Wimsatt’s multi-perspectival realism. It disabuses us of widespread but misleading myths and idealizations about science, such as the idea that everything in the world can be reduced to a fundamental level, or that we can approach a “view from nowhere” — complete and objectively detached knowledge of the world. Wismatt proposes an alternative view based on his thorough studies of actual research practice. It cuts deeply into the layered yet messy structure of reality, and the improvised but potent tools we have available, as limited and evolved beings, to explore it. Wimsatt reframes science as an irregular yet adaptive process rather than a cumulative repository of unalterable facts. His philosophy provides a workable and grounded middle way between radical skepticism and naïve belief in the objective truth of science. It explains how knowledge is conceptually constructed by humans, but still connects us to reality in a trustworthy way. We need such a new view of science, not only to improve our research practices and outcomes but, more generally, to gain a more realistic understanding of ourselves, the world, and our place and role within it.