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Christian Meesters
Christian Meesters
@rupdecat@fediscience.org  ·  activity timestamp 3 weeks ago

@egonw a few days ago, I bumped the #Bioconda package of r-wikipathways to v1.30 . Thank you for this wonderful package!

Today, after quite some tinkering, I managed to overlay differential expression results. This is not stable code, yet. The enrichment is a bit fiddly and the overlay relies on finding the right offsets in a downloaded path figure. But perhaps, I am naive and there is a better way?

Result of an R-Script illustrating downregulation (shades of blue) in a Drosophila pathway. The dataset was small, the results not reliable, the biological interpretation not feasible.
Result of an R-Script illustrating downregulation (shades of blue) in a Drosophila pathway. The dataset was small, the results not reliable, the biological interpretation not feasible.
Result of an R-Script illustrating downregulation (shades of blue) in a Drosophila pathway. The dataset was small, the results not reliable, the biological interpretation not feasible.
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WikiPathways
WikiPathways
@wikipathways@fosstodon.org replied  ·  activity timestamp 3 weeks ago

@rupdecat @egonw please create a PR for this page to link to your package: https://www.wikipathways.org/download.html

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Christian Meesters
Christian Meesters
@rupdecat@fediscience.org replied  ·  activity timestamp 3 weeks ago

@wikipathways @egonw

I don't think so: Only now, I discovered the vignettes and actually read them. My overlay approach is neither visually appealing nor graphically stable. 🤦‍♂️ I will hardly find the time next week, but will start experimenting with RCy3 asap. That ought to solve my little issue.

Once integrated, I will demonstrate a workflow integration (and link that in a PR, promised). Note, this will take some time, given the time of the year and some teaching obligations I have in addition.

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Egon Willighagen
Egon Willighagen
@egonw@social.edu.nl replied  ·  activity timestamp 3 weeks ago

@rupdecat what's the link to that package?

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