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Björn Brembs
@brembs@mastodon.social  ·  activity timestamp 2 weeks ago

@albertcardona

Very interesting! This is not what I got from that article - and glancing at the cited ones.

I understood there was little correlation - I thought this means both ways. I'm not entirely sure how this can be asymmetrical? Is, perhaps, the activity the connectome predicts just a small subset (maybe just rare or even artifical?) of all potential activity patterns in a nervous system?

Albert Cardona
@albertcardona@mathstodon.xyz replied  ·  activity timestamp 2 weeks ago

@brembs

For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.

Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.

#Celegans #neuroscience #connectomics

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Albert Cardona
@albertcardona@mathstodon.xyz  ·  activity timestamp 4 months ago

Position available: Post Doctoral Research Associate in Whole Organism Neuroscience – lab of Iris Hardege, University of Cambridge, UK.

Deadline for application: August 3rd, 2025.

"This BBSRC-funded project aims to understand the interplay between excitatory and inhibitory metabotropic and ionotropic dopamine receptors and how they contribute to the regulation of complex behaviours."

https://www.jobs.cam.ac.uk/job/51874/

#PhDJobs #neuroscience #Celegans #dopamine

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Albert Cardona
@albertcardona@mathstodon.xyz  ·  activity timestamp 4 months ago

Position available: Post Doctoral Research Associate in Whole Organism Neuroscience – lab of Iris Hardege, University of Cambridge, UK.

Deadline for application: August 3rd, 2025.

"This BBSRC-funded project aims to understand the interplay between excitatory and inhibitory metabotropic and ionotropic dopamine receptors and how they contribute to the regulation of complex behaviours."

https://www.jobs.cam.ac.uk/job/51874/

#PhDJobs #neuroscience #Celegans #dopamine

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