When editing the file, turning the layers on/off a lot would be a bit inconvenient. Maybe a dedicated plugin could help with that.
And then, there are some possibilities for making the "renderer" happen:
It could be an external tool that you point at the SVG, and it outputs the PDF, as fast as possible.
It could be an Inkscape plugin; but all I've used felt a bit iffy, I dunno…
It could be a script that does as little as possible, and calls Inkscape on the command line for rendering?