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Albert Cardona
@albertcardona@mathstodon.xyz  ·  activity timestamp 2 weeks ago

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

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