Stop thinking of COVID as if it's an acute cold. Think of it as a neuroinvasive virus you can get every year or two that slowly degrades your brain in ways that will harm your abilities and quality of life throughout your life. (Maybe then you'll pay attention to surges, avoid indoor crowds, and put a mask on when you can.)

Medical research studies are dense and technical but... (2/?)

These data suggest that COVID-19 infection, through the SARS-CoV-2 Spike 1 protein, leads to Alzheimer’s disease–related pathology.
https://www.science.org/doi/10.1126/sciadv.ads5006

The main finding of this study is the identification of significant hypometabolism and EEG slowing in anterior brain regions in patients with persistent subjective cognitive decline after mild COVID-19.
https://www.nature.com/articles/s41598-025-04815-6 (3/?)

This study highlights the potential long-term neurological sequelae in recovered COVID-19 patients as evidenced by changes in white matter structural complexity.
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1580262/abstract

Diffusion tensor imaging (DTI) findings—such as decreased fractional anisotropy (FA) and increased mean diffusivity (MD)—highlight white matter microstructural compromise in individuals with long-term OD (Olfactory Dysfunction).
https://www.mdpi.com/2076-3425/15/7/690 (4/?)

Results suggest COVID-19 is associated with selective structural and functional alterations in basal ganglia–limbic–cortical circuits, with stronger effects in severe cases.
https://www.medrxiv.org/content/10.1101/2025.06.20.25329994v1

This finding, derived indirectly from behavioral performance, suggests compromised hippocampal neurogenesis following infection, which may contribute to COVID-related memory deficits.
https://www.nature.com/articles/s41598-025-04166-2

(5/?)

Neurological symptoms are common and persistent in COVID-19 survivors. The prevalence rates for the different symptoms were as follows: fatigue 43.3%, memory disorders 27.8%, cognitive impairment 27.1%, sleep disorders 24.4%, concentration impairment 23.8%, headache 20.3%, dizziness 16%, stress 15.9%, depression 14.0%, anxiety 13.2%, and migraine 13%.
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-025-04174-9

(6/?)