if anybody out there knows how activity of estrogen receptors vary with zinc concentrations please get in my mentions
because google scholar has locked me out AGAIN and i still want to know
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@bea try searching https://pubmed.ncbi.nlm.nih.gov/ not Google Scholar; PubMed is free and open. If you find a paper you can’t access, try #icanhazpdf
If you want to see what papers are most influential with experts in the field, do the same search at https://icite.od.nih.gov/analysis
Higher RCR = more influential
NB, more influential doesn’t necessarily mean ✨TRUE✨, but it does mean, roughly, this is our current agreement on our best understanding
@bea
You can get some of the same functionality that google scholar offers from pubmed:
https://pubmed.ncbi.nlm.nih.gov/?term=zinc+estrogen
I know that estrogen receptor absolutely requires zinc to function, but it also binds so tightly that you would have to be severely deficient for it to be a problem that way. Interestingly, most of those refs seem to be the other way: effects of estrogen on zinc metabolism.
@stevegis_ssg thanks, yeah i'm interested in finding more about how tightly bound the zinc in the DBD are, and what level of deficiency affects the activity of the receptor, things like that. if i can't find anything directly relevant i'll move on to looking at how intracellular zinc concentrations vary under deficiency, and behaviour of other transcription factors that contain (hopefully similar) zinc fingers
@bea are you looking for a review or primary literature? scifinder (specialty chemistry search engine if you weren't already familiar with it) has a lot of hits for estrogen receptor and zinc concentration so if I have something to narrow it down a bit I could download its results for you? a date range maybe? (sorry this is a bit outside my wheelhouse and I'd rather not send you one paper that isn't all what you want)
@SRLevine primary literature would be lovely. is that something just anyone can use?
@bea Not unless you have university access? It's ridiculously expensive. I think ACS (american chemical society) membership might give you a limited number of searches a month, but that's also expensive.
However if you are at a university they generally do not check that you're in a field where using it makes sense, so usually anyone can make an account to use it.
@SRLevine alas, i have no institution or access. if it was something i could do myself i would be happy to and save you the trouble, but since it's not, whatever you feel like digging up would be amazing.
@bea let me know if there are papers you want that you can't get via anna's archive (scihub mirror) and I'll see what I can do, though if it comes in too late tonight it will have to wait for tomorrow since I'm hopefully going to get out of here in less than 30 min...
@SRLevine @stevegis_ssg yeah after getting kicked off scholar i've been going through pubmed, but no luck so far. if i think of some better search parameters or specific papers i can't get my hands on i'll let you know. thanks very much!