The latest collection of commentary and Essays in @PLOSBiology is devoted to #immunometabolism.

We highlight how the interplay between systemic metabolism and the immune response impact tissue and organismal functions, as well as the therapeutic potential of manipulating immunometabolism.

⚛️ Nicole Chapman and Hongbo Chi advocate for the use of systems biology approaches as discovery tools for new therapeutic targets

💉 Yun Sok Lee investigates the process of metaflammation, the chronic low-grade inflammatory response that occurs in metabolic diseases such as obesity and type 2 diabetes, exploring how systemic changes in metabolism can affect tissue-resident immune cells

🦠 Griffin Gowdy and Alice Prince look at the role of immunometabolites in both driving and combating bacterial infections, with a focus on lung pathogens

🥗 On a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to target immunometabolism through pharmaceutical and lifestyle interventions, with a focus on cancer

The collection was edited by Claudio Mauro, Lucas Smith and Joanna Clarke

#immunology #metabolism #cancer #aging #inflammation #infection

https://collections.plos.org/collection/facets-of-immunometabolism/

The latest collection of commentary and Essays in @PLOSBiology is devoted to #immunometabolism.

We highlight how the interplay between systemic metabolism and the immune response impact tissue and organismal functions, as well as the therapeutic potential of manipulating immunometabolism.

⚛️ Nicole Chapman and Hongbo Chi advocate for the use of systems biology approaches as discovery tools for new therapeutic targets

💉 Yun Sok Lee investigates the process of metaflammation, the chronic low-grade inflammatory response that occurs in metabolic diseases such as obesity and type 2 diabetes, exploring how systemic changes in metabolism can affect tissue-resident immune cells

🦠 Griffin Gowdy and Alice Prince look at the role of immunometabolites in both driving and combating bacterial infections, with a focus on lung pathogens

🥗 On a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to target immunometabolism through pharmaceutical and lifestyle interventions, with a focus on cancer

The collection was edited by Claudio Mauro, Lucas Smith and Joanna Clarke

#immunology #metabolism #cancer #aging #inflammation #infection

https://collections.plos.org/collection/facets-of-immunometabolism/

University of New Mexico #scientist is revealing what might be one of the most overlooked causes of #dementia — damage in the #brain tiny #bloodvessels. Dr. Elaine Bearer has created a new way to classify these changes, showing that many people diagnosed with #Alzheimers also suffer from #vascular damage that quietly destroys #brain tissue. Even more surprising, she’s finding #microplastics inside the brain that appear linked to #inflammation & #memory loss. https://www.sciencedaily.com/releases/2025/10/251005085637.htm #healthcare

University of New Mexico #scientist is revealing what might be one of the most overlooked causes of #dementia — damage in the #brain tiny #bloodvessels. Dr. Elaine Bearer has created a new way to classify these changes, showing that many people diagnosed with #Alzheimers also suffer from #vascular damage that quietly destroys #brain tissue. Even more surprising, she’s finding #microplastics inside the brain that appear linked to #inflammation & #memory loss. https://www.sciencedaily.com/releases/2025/10/251005085637.htm #healthcare