theruran 💻 🌐 :cereal_killer:
boosted
Angela Antunovic
boosted
Angela Antunovic
boosted
phildini
boosted
Postural orthostatic tachycardia syndrome in post-COVID-19 long-hauler patients is associated with platelet storage pool deficiency
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1560120/full
"most #POTS patients have a platelet delta granule storage pool deficiency"
Image is screenshot from latest Science for ME weekly update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @pots
Postural orthostatic tachycardia syndrome in post-COVID-19 long-hauler patients is associated with platelet storage pool deficiency
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1560120/full
"most #POTS patients have a platelet delta granule storage pool deficiency"
Image is screenshot from latest Science for ME weekly update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @pots
So I'm reading https://www.medrxiv.org/content/10.1101/2025.08.08.25333305v1.full-text with interest as it ostensibly found metformin didn't meaningfully decrease Long COVID rates
and
participants didn't receive the metformin until a median five days after symptom onset
they cite other work that found a ~40% reduction in LC with metformin dose:
In the COVID-OUT randomized trial, the HR for participant-reported clinician diagnosis of LC in those randomized to 14 days of metformin was 0.59 (95% CI 0.39 to 0.89)
and I am left wondering if maybe "metformin should be taken as early as possible during acute COVID-19" is what the new study really suggests
#SARSCoV2#COVID#COVID19 #LongCOVID #metformin #CovidIsNotOver
Someone (you know who you are) pointed this https://www.sciencedirect.com/science/article/pii/S2589004224018959 out
which hints that maybe metformin's mechanism of action against LC might be to make it harder for C19 to establish viral reservoirs
haven't read the paper in depth but a very interesting notion
if true then we could expect to see meformin
- reducing LC symptom clusters downstream from persistence, but
- reducing less LC from symptoms downstream from immune dysregulation, direct epithelial and BBB damage, and direct organ damage
So I'm reading https://www.medrxiv.org/content/10.1101/2025.08.08.25333305v1.full-text with interest as it ostensibly found metformin didn't meaningfully decrease Long COVID rates
and
participants didn't receive the metformin until a median five days after symptom onset
they cite other work that found a ~40% reduction in LC with metformin dose:
In the COVID-OUT randomized trial, the HR for participant-reported clinician diagnosis of LC in those randomized to 14 days of metformin was 0.59 (95% CI 0.39 to 0.89)
and I am left wondering if maybe "metformin should be taken as early as possible during acute COVID-19" is what the new study really suggests
#SARSCoV2#COVID#COVID19 #LongCOVID #metformin #CovidIsNotOver
Ika Makimaki
boosted
"A growing number of scientists believe that the SARS-CoV-2 virus may instead be subtly altering our immune systems. If correct, their hypothesis will change how we understand everything from respiratory syncytial virus (RSV) to shingles to sepsis."
God damn, finally.
"A growing number of scientists believe that the SARS-CoV-2 virus may instead be subtly altering our immune systems. If correct, their hypothesis will change how we understand everything from respiratory syncytial virus (RSV) to shingles to sepsis."
God damn, finally.
Angela Antunovic
boosted
More evidence of brain damage from mild COVID-19. Previous studies tested metabolic or electrical activity separately; this one tested both together.
They found both lower metabolism and slower neuron firing in the same brain areas of people with Long COVID.
significant hypometabolism in the bilateral frontal, temporal, and parietal lobes, as well as in the left occipital lobe, along with predominantly frontal EEG slowing in post-COVID-19 patients compared to healthy controls
the functional impact on memory was very strong:
a high incidence of subjective memory decline: 52.9% of post-COVID-19 patients scored more than 1.5 standard deviations [worse than] the normative sample on both the prospective and retrospective memory scales.
1.5 standard deviations is HUGE. That means that in a room of 101 people, lined up from best to worst memory, if person 51 in the middle gets Long COVID, they would expect to end up with the 7th worst memory in the room. From literally average to under the bottom 10%!
Both hypometabolism and changes in spectral power are indicators of underlying neuronal stress or damage
https://www.nature.com/articles/s41598-025-04815-6
discussed by:
https://mastodon.social/@MEActNOW/114785060877455028
https://kolektiva.social/@anarchademic/114797316431201508
https://disabled.social/@tomkindlon/114815026573559502
https://mastodonapp.uk/@PaulSchleifer/114797897931610492
More evidence of brain damage from mild COVID-19. Previous studies tested metabolic or electrical activity separately; this one tested both together.
They found both lower metabolism and slower neuron firing in the same brain areas of people with Long COVID.
significant hypometabolism in the bilateral frontal, temporal, and parietal lobes, as well as in the left occipital lobe, along with predominantly frontal EEG slowing in post-COVID-19 patients compared to healthy controls
the functional impact on memory was very strong:
a high incidence of subjective memory decline: 52.9% of post-COVID-19 patients scored more than 1.5 standard deviations [worse than] the normative sample on both the prospective and retrospective memory scales.
1.5 standard deviations is HUGE. That means that in a room of 101 people, lined up from best to worst memory, if person 51 in the middle gets Long COVID, they would expect to end up with the 7th worst memory in the room. From literally average to under the bottom 10%!
Both hypometabolism and changes in spectral power are indicators of underlying neuronal stress or damage
https://www.nature.com/articles/s41598-025-04815-6
discussed by:
https://mastodon.social/@MEActNOW/114785060877455028
https://kolektiva.social/@anarchademic/114797316431201508
https://disabled.social/@tomkindlon/114815026573559502
https://mastodonapp.uk/@PaulSchleifer/114797897931610492