AFAIK, there hasn't been a hardware implementation of #uxn thus far.
The instruction set is pretty simple, the core is just 100 lines of C. I'd surmise it could be implemented in the very dinkiest #fpga, and using some kind of TTL asic or something (I'm way, way, way beyond my competency, here (and almost everywhere else, lolol)) should be quite doable.
Of course, stuff like graphics would be more complex, as it gives you any 4 colors out of a range of 4096, and the display size can be variable, but it's been implemented on reasonably limited hardware like the #PlayDate and Gameboy Advance.
I'm kind of wondering if anyone has attempted a true 8-bit implementation, like on a #Commodore64. XD
The cell-based coloring system of most 8-bit micros would be challenging to adapt uxn to, unless you just assumed monochrome.